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phrC [2017-8-11 16:0:3]
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phrC [2017-8-11 16:0:3]

response regulator aspartate phosphatase (RapC) regulator / competence and sporulation stimulating factor (CSF)
locus
BSU03780
pI
8.16
mw
4.06 kDa
protein length
40 aa Sequence Blast
gene length
120 bp Sequence Blast
function
control of ComA activity
product
phosphatase (RapC) regulator / competence and sporulation stimulating factor (CSF)
essential
no
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.1|Genetics] → [category|SW 3.1.7|Genetic competence]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.2|Transcription factors and their control] → [category|SW 3.4.2.2|Control of two-component response regulators] → [category|SW 3.4.2.2.3|Control of response regulators/ other]
  • [category|SW 3|Information processing] → [category|SW 3.4|Regulation of gene expression] → [category|SW 3.4.8|Quorum sensing]
  • [category|SW 4|Lifestyles] → [category|SW 4.1|Exponential and early post-exponential lifestyles] → [category|SW 4.1.3|Genetic competence]
  • [category|SW 6|Groups of genes] → [category|SW 6.8|Short peptides]

    • Gene

    Coordinates
    429,963 → 430,085

    The protein

    Catalyzed reaction/ biological activity

  • binds to [protein|242632B27E0E3AB15777E9FBA3FC746D00CE97F9|RapC], this results in the inability of [protein|242632B27E0E3AB15777E9FBA3FC746D00CE97F9|RapC] to interact with [protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|ComA] [Pubmed|12950917]

    • Protein family

  • phr family (according to Swiss-Prot)

    • Structure

  • [PDB|4GYO] (complex [protein|BC28167FE175BFD7DBF1B07C54D3512184B95B8F|RapJ]-[protein|C0B7845F55A16300EB37F026C817AEC4F3BA3B6F|PhrC]) [Pubmed|23526881]

    • Expression and Regulation

    Operons

    genes
    [gene|242632B27E0E3AB15777E9FBA3FC746D00CE97F9|rapC]-[gene|C0B7845F55A16300EB37F026C817AEC4F3BA3B6F|phrC]
    description
    [Pubmed|10464187]

    sigma factors

  • [protein|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA]: sigma factor, [Pubmed|10464187], in [regulon|360F48D576DE950DF79C1A2677B7A35A8D8CC30C|SigA regulon]
  • [protein|DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|SigH]: sigma factor, [Pubmed|10464187], in [regulon|DC3449D5F195E5C2E9E14FEC95396C8F1FDF73B4|SigH regulon]

    • regulatory mechanism

  • [protein|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|CodY]: repression, [Pubmed|10464187], in [regulon|90ACE0DECA58D3C1A55E135120F7A0C1C920571C|CodY regulon]
  • [protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|ComA]: activation, ([protein|7832489F11F606BCF637EC23BAAB41AD10237EBB|ComA]) [Pubmed|16091051], in [regulon|7832489F11F606BCF637EC23BAAB41AD10237EBB|ComA regulon]
  • [protein|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA]: repression, [Pubmed|12850135], in [regulon|E39AFEB7B7F28969A35C4B51CC6E7819F71C79D9|CcpA regulon]

    • regulation

  • expressed at high cell density ([protein|search|ComA]) [Pubmed|16091051]
    • view in new tab

    genes
    [gene|C0B7845F55A16300EB37F026C817AEC4F3BA3B6F|phrC]
    description
    [Pubmed|10464187]

    regulation

  • expressed at high cell density ([protein|search|ComA]) [Pubmed|16091051]
    • view in new tab

    References

    Reviews

  • 22024380

    • Original publications

  • 12950917,16816200,19202088,18375560,11267663,10464187,12850135,16091051,23526881,22511326